https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14134 1D- subtype compared to α_1A- and α_1B-ARs. 9 out of 12 of the tested compounds displayed affinity at the α_1A and α_1D -AR subtypes and 6 displayed affinity at all three α₁-AR subtypes, no α_1B-AR selective compounds were identified. 8 of the 9 compounds with α₁-AR affinity were antagonists and one compound displayed partial agonist characteristics. This virtual screening has successfully identified an α_1A/D-AR selective antagonist, with low µM affinity with a novel structural scaffold of a an isoquinoline fused three-ring system and good lead-like qualities ideal for further drug development.]]> Wed 11 Apr 2018 14:43:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14610 Sat 24 Mar 2018 08:20:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21540 Sat 24 Mar 2018 07:50:24 AEDT ]]>